Tirzepatide, now in phase 3, and bimagrumab, in phase 2, are illustrative of what is likely to make an impact on clinical practice
Akkermansia benefits Early research, including the first proof-of-concept human study, points to several potential benefits of Akkermansia, most centered on the gut: Gut barrier support: Helps maintain the protective mucus layer of the intestinal wall
Interim analysis of the EAGLE trial: an open-label study to assess the long-term safety and tolerability of bardoxolone methyl in patients with alport syndrome: PO1300
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Palatable food dampens the long-term behavioral and endocrine effects of juvenile stressor exposure but may also provoke metabolic syndrome in rats
Poor diet, lack of sleep, and modern lifestyle further trigger this imbalance, resulting in: Collagen breakdown, driven by enzymes called matrix metalloproteinases (MMPs) Impairment in skin barrier function causes dryness, reduced hydration, and skin sensitivity Increased inflammatory signals like interleukin-1 (IL-1), triggering skin aging This ultimately leads to visible skin changes, including dullness, fine lines, and uneven pigmentation